However I don't think anyone makes a new forum account just to advertise some other game in the Off-topic section, unless they have some kind of an agenda. Frostmire (whose username is lifted straight from Shadow Era btw) could be a veteran of Card Hunter and might some day even post non-Shadow Era related stuff, in which case I do apologize sincerely. ![]() Just because someone says they are just a regular Joe, does not mean they are, unless you want to live your life believing everything you are told, which I personally don't. Marketing shills have been around ever since the first gaming forums appeared. These forums seem to have a pretty laid back attitude towards moderating (not deleting name-and-shame topics etc.) so I guess topics like this one are fine, which is good for a gamer like myself.īut I will add that it would be really naive to assume that all newly joined members who post only about some other game are just average gamers like you and me. But like I said, it all depends on the devs and how they want to run things. While it might be great for players to learn about new games, it's not that great for developers because some players could stop playing (and paying) Card Hunter and switch to those new games instead. Sure we all play CCG's and are interested in them, but this is not a general gaming forum, it's a Card Hunter forum. You are looking at this thing from a players perspective whereas I am looking at it from the developers perspective. An ad is and ad whether you advertise games or fake watches. Just because it's "Off-topic" does not mean it's also "No rules, anything goes" where anyone can make a new account and start posting their Viagra ads. If they don't want other devs or "fanbois" to be able to advertise their games for free, topics like this one should be deleted, like they often are on other forums. ![]() Click to expand.Well, it all depends on how BM wants to run these forums.
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Rule 2: Questions should spark discussion Please avoid derailing such discussions into general political discussion, and report any comments that do so. In particular, any political discussion on /r/math should be directly related to mathematics - all threads and comments should be about concrete events and how they affect mathematics. All posts and comments should be directly related to mathematics, including topics related to the practice, profession and community of mathematics.Īll posts and comments should be directly related to mathematics, including topics related to the practice, profession and community of mathematics. This subreddit is for discussion of mathematics. ![]() Safari browser runs fewer individual processes than Chrome and is generally less processor-intensive. Apple provides a secure hardware environment. According to various sources, using Chrome over Safari costs as much as an hour of battery life daily. Apple has designed Safari in such a way that enables the opportunity to maximize battery on its products. It offers you to save the passwords to your keychain.Ĭhrome browser takes a toll on the battery life of the computer. Safari was the first browser to provide such an opportunity. There is one feature that Google Chrome has recently started to provide, which is suggesting the user an auto-generated super-strong password. The autofill feature also covers the security codes for two-factor authentication, which are enabled by third-party companies. Remembering passwords is no longer required you would have to enter your credentials only once. ![]() You can enter into an account with the help of face id. The password manager is a feature for both iOS and macOS Mojave, and it will make your life easier on the web infinitely. The graphics integration allows the safari to offer a smoother scrolling experience and sharper feedback while using fewer system resources than other browsers. It also takes a relatively small portion of the primary memory as compared to its counterparts. The page loading time isn’t vastly different between the two browsers. Safari is far more responsive to user input than Chrome. A new version of Intelligent Tracking Protection provides the latest update that keeps third parties from tracking your footsteps. ![]() Safari is the only browser that respects the privacy of the user. Here are the reasons why should you use Safari is better than another browser. According to Apple’s sources, the browser outperforms other browsers like Chrome and Firefox in terms of speed and performance. With a plain-vanilla layout and a clutter-free user interface, Safari runs smoothly on your Windows 10 PC. Why should you download and install Safari for Windows? It has also enabled cross-browser Encrypted Media Extensions (EME) by adding APIs without the WebKit prefix. ![]() The new update has added the support for simulcast and VP8 in WebRTC to improve support for multi-party video conferencing. You can click on the AirPlay icon on compatible videos and watch them on different portable screens. It allows you to play Video from a web page to your TV or any other device. This feature is also available on the Safari browser. AirPlay:Īpple AirPlay is a proprietary protocol suite that offers the user to stream between devices of audio, video, device screens, and photos, together. This feature is now available on various other web browsers as well. It prevents these sites from loading and gives a warning if a site looks suspicious. Safari protects you from fraudulent malware/adware websites. This feature makes the browser more comfortable and calm by changing the color scheme to create web pages more accessible to read at night time. With the release of Safari 12.1, the browser offers the ability to enable color scheme customizations for websites while in Dark Mode. Improved Intelligent Tracking Prevention limits long-term tracking based on client-side first-party cookies and to verify partitioned cache entries. The Storage Access API now enables third-party access to cookies. With the release of Safari 12, the browser has stopped the support for partitioned cookies for domains with cross-site tracking abilities. It has removed the support for the expired Do Not Track standard to prevent potential use as a fingerprinting variable.Added warnings are sent to the user when they load insecure pages in both Safari.The new update includes the following features: Safari is the only browser on the internet with the DuckDuckGo feature, a search engine with no built-in option to track you. Here we will discuss some of its distinctive features. The browser is user-friendly and compatible with all devices from PCs to laptops, mobile phones, and tablets. Building upon the company’s reputation, Safari has managed to impress its users with unique features and simple design. Safari 12 is the latest version of the browser to be released. What are the Standout Features of Safari Browser? Why should you download and install Safari for Windows What are the Standout Features of Safari Browser ![]() First Aid Beauty Limited Edition Ultra Repair Cream Pink Grapefruit. So this time when my Dad came, he brought 5 to 6 huge tubes of these for both of us *hihi* On the whole, this is a must-have for oily-skinned beauties and the dry-skinned ladies can also give it a try. Neutrogena11 Products Available11 Nivea1 Products Available1 No78 Products. And the main part- it did not dry her skin. It cleaned my face well and I found that I didnt react with it. She says it keeps her skin clean and smooth. This review was collected as part of a promotion. With naturally derived grapefruit extract plus vitamin C, this oil-free scrub features gentle exfoliators that smooth away roughness without over-drying or irritating acne-prone skin. Wipes clean with no greasy or oily residue, so theres no need to rinse. Mostly, the ones with dry skin might be thinking of giving such oil-free scrubs a skip. Our acne face scrub powerfully clears blemishes and blackheads with maximum strength Salicylic Acid acne-fighting medicine plus an uplifting blast of grapefruit. NEUTROGENA® Oil-Free Cleansing Wipes Pink Grapefruit sweep away pore-clogging impurities and oil in one simple step, providing effective cleansing for acne-prone skin. For reference, she has dry and clear skin. The last time Dad got this, my mum gave it a try as well. This product has worked very well for me. Ens began researching the product online and discovered hundreds of complaints from people who say they experienced similar inflammation after using two of Neutrogena's grapefruit products: Neutrogena's Oil-Free Acne Wash Pink Grapefruit Facial Cleanser and the Oil-Free Acne Wash Pink Grapefruit Foaming Scrub. ![]() *nonono* One needs to have a well planned beauty regime- make time for yourself everyday and see that you don’t skip that routine. Find helpful customer reviews and review ratings for Neutrogena Oil-Free Acne Wash Scrub, Pink Grapefruit, Value Size, 6.7 Ounce at. I will not say using this alone can make you love your skin. oz Quality Choice Oil Free Pink Grapefruit Acne Wash, Foaming Scrub for All Skin Types, 2 Salicylic Acid, Skin Treatment, 4. I don’t have to worry about any acne anymore. Neutrogena Oil-Free Salicylic Acid Pink Grapefruit Pore Cleansing Acne Wash and Facial Cleanser with Vitamin C, 9.1 fl. 33. Rated 5 out of 5 by francisandreag from Helps With acne helps with breakouts alot and keeps the face feeling good after washing it reccomend always using it to keep the acne away overall the exfoliating of the little balls on it feels and smells great also veryy. 2 years back my skin had a lot of acne and reacted horribly to any product. Oil-Free Acne Wash Pink Grapefruit Foaming Scrub is rated 3.9 out of 5 by 2521. At the same time, it doesn’t work on removing blackheads that much since it is very mild. This one is a mild scrub and it works beautifully on my skin. I have tried many scrubs in the market but everything I tried were either harsh or dried my skin completely. I don’t want to part with this scrub ever. Result– I have been using this scrub for almost 2 years now and still counting. ![]() It provides greater flexibility to businesses, allowing them to choose the most efficient mode of transportation for each leg of the shipment. Typically, transloading occurs when a shipment cannot be transported directly to the location of the shipment via a single method of transport. Transloading involves moving freight from one mode of transportation to another, usually from truck to rail car or rail car to truck. While “transloading” and “intermodal” are often used interchangeably, they are two distinct shipping practices with some key differences. While it is often necessary for the shipping process, it also presents an opportunity to optimize logistics and improve efficiency.īy utilizing transloading services, businesses can reduce transportation and storage costs, expedite delivery times, and streamline transportation operations. The most frequent transloading practice in the United States involves transferring cargo from rail car transport to a truck, typically using a flatbed truck, flat car, or box car. More precisely, transloading involves transferring only the products themselves and not the entire container. Transloading is a crucial step in the supply chain involving the transfer of freight from one mode of transportation to another, for example, trucks, rail cars, or ships. ![]() We will explore the advantages of transloading and its versatility in handling a wide range of goods. In this article, we will delve into the world of transloading, examining how it can help businesses navigate the complexities of modern transportation and stay ahead of the competition. So, what exactly is transloading? Transloading refers to the process of transferring goods from one mode of transportation to another, providing businesses with a dynamic approach to simplifying freight transportation methods. The growing demand for transloading services is driven by the surge of international trade and e-commerce in recent years. This dynamic approach has become increasingly important and has grown in popularity during the current economic climate, as the cost of living crisis continues to put pressure on individuals and families, companies have been forced to explore new and innovative ways to stay competitive in a world of increased international trade. Transloading is a vital solution provided by transportation experts to help businesses optimize their logistics and make freight transportation faster, more efficient, and more economical. Removal of Document(s) that were Erroneously Filed to the Record, (i.e., Document Filed in your Record Contrary to Policy or Regulation such as Birth Certificate LOA/LOC’s). Removal of Document(s) Belonging to Someone Else Removal of Document(s) that were Corrected by Another Document (Both Documents Must Already be in the OMPF Record) The most common corrections to the image record (OMPF) are (if the correction pertains to Evals/FitRep – see above): Note: Correcting your image record (OMPF) does not correct your Personal Data Record (see Personal Data Record above). Our "Contact Us" page provides an email address to which you can submit corrections. OMPF Image Documents - To correct documents in your OMPF record see our webpage’s Document Correction, Document Submission, Frequently Asked Questions (FAQ), and Contact Us.īefore submitting corrections to us, please review the webpages above. PERS-313 does not correct Personal Data Records. If they are unable to correct, they will know who to contact to correct corporate data. Please contact your Personnel Office or NSIPS for assistance in correcting personal data records (corporate data). Personal Data Record – Your Personal Data Record (corporate data) to name a few such as ESR, PSR, ODC, ETJ, and NDAWS is updated by various other agencies such as your servicing Personnel Office or NSIPS. CorrectionsĮvaluations/Fitness Reports - For all Evaluations or Fitness Reports issues (this includes removal of duplicates/someone else’s report(s)), please contact PERS-32. With "OMPF - My Record" you are able to view, download and print the documents as you would with the documents on the CDROM. Documents that have been sent to Navy Personnel Command (NPC) within the past few months may still be in process of being scanned to the OMPF record. Your OMPF reflects documents that have been received, reviewed, and accepted as an official document. Remember once document(s) are scanned to the OMPF record here at NPC they are destroyed - See Records Management and Policy. The CD should be kept in a safe and secured place. ![]() ![]() backup file document loss due to system-file corruption). ![]() Ordering a CD should only be done for retaining your complete OMPF record on CD for emergency situations (i.e. OMPF - My Record provides a secure and efficient method for you to access and review your image record 24/7 and is the preferred method of obtaining OMPF information and correcting your records (see Corrections below) vice ordering the OMPF on CDROM (eliminates unnecessary delays caused by waiting days/weeks to received a CD). All active duty and reserve personnel having a BOL account, a Common Access Card (CAC) and a CAC-enabled computer can now view their OMPF record online by selecting the "OMPF - My Record" link under the BOL Application Menu. ![]() McCall Media accepts checks, Paypal, or payment online by card via Square. Upon delivery of photos, you will receive a pdf copy of the invoice in your email, with instructions for payment. We won't hold your images hostage and make you pay before getting to see them first. Payment is always due 15 days from the date the photos are delivered. We want to make sure you are satisfied with your pictures. The web sized photos are much smaller file sizes and are therefore easier to work with, load faster, and are sized and optimized for online use, such as MLS listings, Zillow,, Facebook etc. We’ve found this to be a very simple and user-friendly method for sharing files, and you won’t need to have Dropbox installed or have a Dropbox account to receive your photos.įor every shoot, you will receive two sets of the images - "high resolution" and "web sized." The high-res photos are very large files in their full resolution which are ideal for printing in larger sizes, such as magazine covers or brochure. The photos will remain backed up in the cloud via dropbox unless you delete them. WHAT IF IT'S OVERCAST/CLOUDY? WILL THE PHOTOS STILL LOOK GOOD?įinal, edited images are always uploaded to Dropbox. Once the photos are finished and ready to be delivered, you will receive an email with a link to view and download the photos. However, as a courtesy please give us 24 hours notice in the event a photo shoot needs to be rescheduled. McCall Media never charges a cancellation fee. No problem! We know things come up that may delay a property being ready for photos. The first 40 miles round-trip from Coeur d'Alene are always free, and any mileage beyond that is billed at $.1.20/mile. We typically stay within about an hour’s drive from Coeur d’Alene. We are happy to work around you and your seller's schedule. ![]() McCall Media is available to shoot your property 6 days a week (Monday-Saturday). WHEN ARE YOU AVAILABLE TO SHOOT A PROPERTY? You will promptly receive a high-quality set of photos with wide fields of view showcasing entire spaces without distortion, vivid, accurate colors and clarity that rivals how the naked eye sees.Ī homebuyer's initial impression of a property will be based on the photos they see in the listing. What you can expect when hiring McCall Media is a photographer who arrives on time at the right place and who works in a professional manner. McCall Media has photographed thousands of properties for many of the area's top-producing realtors and home builders since it’s inception in 2011. When you hire McCall Media to shoot your property, you can rest assured you have an experienced professional with the proper equipment, and more importantly, the eye to know which angles to shoot from, which features about the property to showcase, and how to properly edit the photographs to bring them to their fullest potential. ![]() He said: “This is the saddest day for Staffordshire in my 47 years’ association with the county. December 10, 1993: A miner can be seen clearing out his Pithead Baths locker, with what could be his son looking onĬounty Council chairman John O’Leary was equally scathing. Only a year before the axe fell, Littleton had set a new record for mining one million tonnes of coal in the fastest time. Mining skills will be lost, young men thrown on the dole during a recession and there will be a huge financial loss to the community.” “The deep mining of coal should have continued in Staffordshire well into the 21st century, instead the effect of Littleton Colliery closing with the loss of 600 miners’ jobs and probably some 1,200 support and service jobs will be devastating to the Cannock area. In an angry letter to the Chase Post, Huntington Parish Council chairman Jeff Ashley seethed: “The tragedy is that there are millions of tonnes of high quality, mineable and economically viable coal left underground. It was a funeral march by the remaining 600 strong workforce and those who witnessed it – this writer included – were left with the same sense of loss, anger and injustice that comes with a passing. Scottish pipers played a mournful Littleton lament on the day the colliery died, while workers marched behind them like heroic soldiers returning from war. A procession lamenting the closure of Littleton colliery walking through Cannock in December 1993 I witnessed the death rattle of its last day. I was there for Littleton’s pomp – in the early 1980s, 2,000 were employed at the pit. ![]() Walk past the terraced homes of Monkey Row, built in the early 20th century for pit workers, and you can almost hear the crisp echoes of boots as workers march en masse in sunlight to the darkness of their daily grind.įrom my own first footsteps in journalism, in the mid 1970s, through 25 years as editor of local weekly paper the Chase Post, Huntington was my patch. In a small memorial garden in the heart of the parish, 660 bricks are etched with the names of miners. Yet the pride in what they achieved and endured remains. The men of Littleton who laboured like moles in the maze of shafts have long gone or found salaries on the surface. A Flag of St George flies on its pinnacle. The 150ft pit mound, once an ugly blemish that cast a threatening shadow over homes below, has been transformed into Littleton Leisure Park, the blackened by-product of a decaying industry now disguised by trees. There’s a shrine to the mine at Littleton Lodge Care Home, with detailed scale model of the pit and a National Union of Mineworkers’ banner carried defiantly on the last day of the doomed colliery. Littleton Colliery has long gone, yet its name remains on a host of landmarks. Yet it is still visible, like the thin blue scars that adorned the weathered faces and arms of miners I interviewed all those decades ago. It is an indelible memory of a lost life, a hard, past life. The black stuff that sustained so many lives in the village – a ribbon of homes stretched between Cannock and Stafford – still stains every street. This is the only resource we have from the forums to point you to for further information on invalid or revoked serial numbers: Īlso in all fairness, there is no need to have to use CS6 versions of apps as they are grossly outdated. If you started to receive errors on an application I would have typically recommended you contact Adobe at that point as a place like GeekSquad has limited options other than to re-install things. As this is a user-to-user support forum there is less we can do here than what Adobe support was able to offer you. This is why they asked about the store you purchased from. There were a number of fraudulent vendors back in the day selling invalid licenses or trying to resell volume licenses which would make your license invalid. Unfortunately what you are asking cannot be done. I do not want the Creative Cloud apps - I need to use the CS6 versions of Dreamweaver, Photoshop, and Acrobat Pro. ![]() I also spoke with Krishna and Satshi who were not helpful, demanded the name of the store that I purchased the software from, advised that it was not genuine, and tried to sell me a subscription to Creative Cloud. ![]() I advised that was not possible since I am the person who registered the product. The first representative (Nathan) advised that I purchased "limited-time software" and that my license key was registered to another Adobe account. Today (11/7/22), I contacted Adobe with the number provided by Geek Squad (86). Geek Squad recommended that I contact Adobe Support to have my license reinstated since the software is legimiate (original packaging, disk, key with barcode). I am receiving messages stating the license is revoked. Yesterday 11/6/22, Geek Squad reinstalled Adobe CS6, but received another error message when trying to complete installation. Geek Squad confirmed it was not a virus or malware. ![]() On 11/5/22, I spent most of the day troubleshooting this with Geek Squad as I thought it might be a virus. Two weeks ago, notifications from Adobe started displaying on my screen when I opened Adobe applications. ![]() There are several approaches for extracting CDR data from sequencing reads and determining the clonotype. 7, 18 This approach has provided an estimation of approximately 10 6 unique TCR sequences present in a human individual. 16, 17 Recent next-generation sequencing (NGS) technologies have offered significant advantages over these earlier methods and have enabled extensive, comprehensive high-throughput measurement and analyses of the diversity of both TCRs and B-cell receptors (BCRs) to elucidate immune functions in health and disease. Using techniques such as Southern blot hybridization, polymerase chain reaction and flow cytometry, researchers have characterized T-cell proliferation. In addition, quantitative assessment of T-cell clones can be of important prognostic significance to manage patients and their treatment. 8 Analysis of the TCR repertoire can thus characterize the host T-cell immune status in patients and normal individuals. 12, 13, 14 In contrast, clonal populations are a hallmark of malignancy, and clonal or oligoclonal populations of T and B cells can also occur in non-malignant conditions including human immunodeficiency virus and Epstein–Barr virus infections. 11 In normal individuals, the TCR repertoire is polyclonal and non-static. 10 The clonotype of a TCR population is a molecular description of the unique sequences (typically described from the amino acid perspective) required to produce the antigen specificity of TCRs, as well as the specific V and J genes involved in the composite rearrangements. The ability of human T cells to recognize a vast range of pathogens and initiate specific adaptive immune responses depends on the versatility of the TCR population. 1, 9 Thus, the sequence of CDR3 and the identity of the flanking V and J gene segments are widely used to classify TCR variants. 7, 8 The vast majority of TCR variation is within complementarity-determining region 3 (CDR3), which encompasses the VDJ recombination junctions and encodes the portion of the TCR that directly contacts peptide-bound major histocompatibility complex molecules. 3, 6 Because this somatic rearrangement occurs only in the T-cell genome and produces an extremely diverse repertoire of TCRs as a hallmark of the cellular adaptive immune system, it can be effectively used as a unique tag to enumerate and quantify T-cell clonality. 4, 5 An individual’s TCR repertoire is shaped by biases during the process of VDJ recombination and by the subsequent expansion and deletion of certain T-cell clones upon antigen recognition during T-cell development in the thymus and later in the periphery. 3 The TCR consists of a heterodimer of two chains (αβ or γδ), both of which are products of V(D)J recombination. 1, 2 This process is directly analogous to the generation of antibody diversity by somatic VDJ recombination of the B-cell receptor locus in B lymphocytes. The T-cell receptor (TCR), which is generated through random rearrangement of genomic V(D)J-variable(diversity)joining-segments, is the mediator of specific antigen recognition by T lymphocytes. Thus, determining monoclonal architecture and clonal diversity by RNA sequencing might be useful for prognostic purposes and for personalizing ATL diagnosis and assessment of treatments. CDR3 sequence length distribution, amino acid conservation and gene usage variability for ATL patients resembled those of peripheral blood cells from ACs and healthy donors. ACs, CD4 -positive samples and smoldering patients showed significantly higher TCR diversity compared with chronic, acute and lymphoma subtypes. Expression of TCRα and TCRβ genes in the dominant clone differed among the samples. Based on these TCR profiles, CD4-positive cells and ACs showed polyclonal patterns, whereas ATL patients showed oligo- or monoclonal patterns (with 446 average clonotypes across samples). We analyzed 62 sets of high-throughput RNA sequencing data from 59 samples of HTLV-1−infected individuals-asymptomatic carriers (ACs), smoldering, chronic, acute and lymphoma ATL subtypes-and three uninfected controls to evaluate TCR distribution. Here we examined the diversity of TCR clonality and its association with pathogenesis and prognosis in adult T-cell leukemia/lymphoma (ATL), a malignancy caused by infection with human T-cell leukemia virus type-1 (HTLV-1). The TCR repertoire can be altered in the context of infections, malignancies or immunological disorders. High-throughput sequencing technologies now allow examination of antigen receptor repertoires at single-nucleotide and, more recently, single-cell resolution. The diversity of T-cell receptor (TCR) repertoires, as generated by somatic DNA rearrangements, is central to immune system function. |
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